Information on EC 2.3.3.8 - ATP citrate synthase. Res. Protein knowledgebase. These are stable identifiers and should be used to cite UniProtKB entries. UniProtKB. from the sequence. Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites (By similarity). RRID: AB_2844433 Please cite this product as: Affinity Biosciences Cat# AF4368, RRID:AB_2844433. UniProtKB. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.
,This subsection of the 'Entry information' section provides one or more accession number(s). Here, we show ATP citrate lyase (Acly) to be activated in inflammatory macrophages and human atherosclerotic plaques. Biophys. A cofactor is any non-protein substance required for a protein to be catalytically active. Format: Liquid.
Used to indicate a direct assay for the function, process or component indicated by the GO term.
The current subsections and their content are listed below:,This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.
,The checksum is a form of redundancy check that is calculated using the generator polynomial: x64 + x4 + x3 + x + 1. with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018. UniParc. Specific Activity: >= 440 pmole… We demonstrate that myeloid Acly deficiency induces a stable plaque phenotype characterized by increased collagen deposition and fibrous cap thickness, along with a … Priority is given to the annotation of physiological ligands.
,This subsection of the Function section indicates at which position the protein binds a given metal ion. ATP citraat lyase is een enzym dat bij dieren een belangrijke stap in de biosynthese van vetzuren.ATP citraat lyase is belangrijk dat, door het omzetten van citraat tot acetyl CoA, verbindt het metabolisme van koolhydraten, die citraat als tussenproduct oplevert, en de productie van …
Others, such as most vitamins, are organic.,Manually curated information which has been propagated from a related experimentally characterized protein.
Systems used to automatically annotate proteins with high accuracy: Select one of the options below to target your search: Select item(s) and click on "Add to basket" to create your own collection here (400 entries max),Manually curated information for which there is published experimental evidence.
ATP-citrate (pro-S-)-lyase. The algorithm is described in the ISO 3309 standard. SWISS-MODEL Repository entry for P53396 (ACLY_HUMAN), ATP-citrate synthase. Protein Ontology. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.,This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.
,This subsection of the Names and taxonomy section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.
,This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All, DNA Data Bank of Japan; a nucleotide sequence database, Ensembl eukaryotic genome annotation project, Database of genes from NCBI RefSeq genomes, KEGG: Kyoto Encyclopedia of Genes and Genomes, Antibodypedia a portal for validated antibodies, BioGRID ORCS database of CRISPR phenotype screens, ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data, The Stanford Online Universal Resource for Clones and ESTs, ProtoNet; Automatic hierarchical classification of proteins, MobiDB: a database of protein disorder and mobility annotations. PR:000003628 ATP-citrate synthase (term hierarchy) EC.
Manually curated information for which there is published experimental evidence.
It is useful for tracking sequence updates. 1,100: Annotation score: Experimental Info. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.,This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.
,This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). UniParc. Here we report cryo‐EM structures of human ACLY alone or bound to substrates or products.
Citrate cleavage enzyme ... ATP citrate synthase. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the IntAct database. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.,This subsection of the Names and taxonomy section is present for entries that are part of a proteome, i.e. When the nitrogen source is exhausted in the medium, the key intermediate, citrate, is converted to acetyl-CoA by ATP:citrate lyase (ACL) for lipid accumulation. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. ATP-citrate (pro-S-)-lyase. This subsection complements the information provided at the sequence level or describes modifications for which position-specific data is not yet available.
. of multiple genes (paralogs). using the generator polynomial: x64 + x4 + x3 + x + 1. In nervous tissue it may be involved in the biosynthesis of acetylcholine. This is known as the 'taxonomic identifier' or 'taxid'.,This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. ATP citrate lyase ATP citrate lyase Identifiers Symbol ACLY Entrez 47 HUGO 115 OMIM 108728 RefSeq NM_001096 UniProt P53396 Other data EC number 2.3.3.8 Locus
This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.
Sequence statusi: Fragment. Enhanced glucose and lipid metabolism is one of the most common properties of malignant cells. Acly. in the absence of the CoA acceptor, the enzyme contains a freely diffusible highly reactive intermediate, with similar properties to other high-free-energy phosphotransfer intermediates such as aminoacyl adenylates; mechanism from the sequence. ATP-citrate synthase, citrate-binding domain IPR032263 PF16114 : 496-600: CoA-binding IPR003781 PF02629 : 660-784: ATP-citrate lyase/succinyl-CoA ligase IPR005811 PF00549 : 888-1081: Citrate synthase IPR002020 PF00285 Commun. Nature 568(7753):571-575 (2019) Verschueren KHG, Blanchet C, Felix J, Dansercoer A, De Vos D, Bloch Y, Van Beeumen J, Svergun D, Gutsche I, Savvides SN, Verstraete KIt should be noted that while, in theory, two different sequences could Human ATP citrate lyase / ACLY ELISA Kit from Assay Genie is a pre-coated immunoassay with a sensitivity of 0.938 IU/ml and a range of 1.56-100IU/ml and has been designed to measure Human ATP citrate lyase / ACLY ELISA Kit in serum, plasma & cell culture supernatant samples. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.
,When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.
,This indicates the type of evidence that supports the existence of the protein.
,This subsection of the Function section describes the catalytic activity of an enzyme, i.e. Because acetyl-CoA is an essential building block for cholesterol and triglycerides, Acly has been considered a therapeutic target for hyperlipidemias and obesity. Gene names ... UniProt is an ELIXIR core data resource. Cyclic redundancy and other checksums
Phospho-ATP citrate lyase (Ser455/Ser457) Antibody detects endogenous levels of ATP citrate lyase only when phosphorylated at Ser455/457. Protein kinase B (Akt) plays a central role in cellular regulation, although many of the physiologically relevant substrates for the kinase remain to … Has a central role in de novo lipid synthesis. Protein sets from fully sequenced genomes.
This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.
,This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.
,This subsection of the 'Interaction' section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the 'Function' section).
,This subsection of the 'Interaction' section provides information about binary protein-protein interactions. IPR032263 ATP-citrate synthase, citrate-binding domain. Protein sets from fully sequenced genomes. Help. Homo sapiens (Human) ATP-citrate lyase (ACL) is a homotetramer that catalyzes the formation of acetyl-CoA and oxaloacetate (OAA) in the cytosol, which is the key step for the biosynthesis of fatty acids, cholesterol and acetylcholine, as well as for glucogenesis (1). Transfected COS cells expressed detectable levels of an enzymatically active recombinant ATP-citrate lyase … The version number for both the entry and the canonical sequence are also displayed.
,This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).
, The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation, transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer, ATP-citrate synthase beta chain protein 1. have the same checksum value, the likelihood that this would happen Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.,This section provides any useful information about the protein, mostly biological knowledge.
. The information is filed in different subsections. UniProt. 121kDa(Calculated). Manual assertion inferred from sequence similarity toi, Manual assertion inferred from sequence similarity toi, Reactome - a knowledgebase of biological pathways and processes, SwissLipids knowledge resource for lipid biology, Mouse genome database (MGD) from Mouse Genome Informatics (MGI), ChEMBL database of bioactive drug-like small molecules,Manually validated information inferred from a combination of experimental and computational evidence.
This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.
Sequence statusi: Complete. is extremely low. Manual assertion inferred from sequence similarity to,This subsection of the Function section describes the interaction between a single amino acid and another chemical entity. … It always involves more than one amino acid and includes all residues involved in nucleotide-binding.
,The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:
,Inferred from Direct Assay
2009 May 22;324(5930):1076-80. doi: 10.1126/science.1164097. Deacetylated by SIRT2 (By similarity). SWISS-MODEL Repository - a database of annotated 3D protein structure models, Database of comparative protein structure models, evolutionary genealogy of genes: Non-supervised Orthologous Groups, The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms, Gene3D Structural and Functional Annotation of Protein Families, Integrated resource of protein families, domains and functional sites, PIRSF; a whole-protein classification database, Simple Modular Architecture Research Tool; a protein domain database, Superfamily database of structural and functional annotation, PROSITE; a protein domain and family database. Phosphorylated by PKA and GSK3 in a sequential manner; phosphorylation results in activation of its activity (By similarity). 491: Annotation score: ... UniProt is an ELIXIR core data resource. Manual assertion inferred by curator fromi,Manually curated information which has been propagated from a related experimentally characterized protein.
The algorithm is described in the ISO 3309 standard. 2.3.3.8. Phosphorylation results in activation of its activity (By similarity). Citrate cleavage enzyme UniRule annotation. ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Protein knowledgebase. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.,A UniProt proteome can consist of several components.
The component name refers to the genomic component encoding a set of proteins.
This section provides information on the location and the topology of the mature protein in the cell.
,This section provides information on the disease(s) and phenotype(s) associated with a protein.
,This section describes post-translational modifications (PTMs) and/or processing events.
,This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.
,This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding lipids, glycans and protein cross-links.
,Manually validated information inferred from a combination of experimental and computational evidence.
ATP-citrate lyase (Acly) is one of two cytosolic enzymes that synthesize acetyl-coenzyme A (CoA). It is useful for tracking sequence updates. ,When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.
,This indicates the type of evidence that supports the existence of the protein. By converting citrate to acetyl-CoA, the enzyme links carbohydrate metabolism, which yields citrate as an intermediate, with fatty acid biosynthesis, which consumes acetyl-CoA. x; UniProtKB. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes generation of acetyl-CoA from citrate.
RNAct, Protein-RNA interaction predictions for model organisms. 336:496-506(2005), succinate/malate CoA ligase beta subunit family, succinate/malate CoA ligase alpha subunit family. of multiple genes (paralogs). Predicted band size: 120 kDa 5% SDS PAGE Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniProtKB. ATP‐citrate lyase (ACLY) synthesizes cytosolic acetyl‐CoA, a fundamental cellular building block. You are using a version of browser that may not display all the features of this website. IPR033847 ATP-citrate lyase/succinyl-CoA ligase, conserved site. Berwick D.C., Hers I., Heesom K.J., Moule S.K., Tavare J.M. ATP-citrate lyase (ACL) is a homotetramer that catalyzes the formation of acetyl-CoA and oxaloacetate (OAA) in the cytosol, which is the key step for the biosynthesis of fatty acids, cholesterol and acetylcholine, as well as for glucogenesis (1). Secondary used is … View PDF In Frontiers in Immunology on 21 December 2018 by Namgaladze, D., Zukunft, S., et al.. ... IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site. Mol.Wt 125kD; 121kDa(Calculated). Ubiquitination is probably inhibited by acetylation at same site (By similarity). Manual assertion based on experiment ini,Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.
Help. SwissPalm database of S-palmitoylation events, Bgee dataBase for Gene Expression Evolution, ExpressionAtlas, Differential and Baseline Expression, Genevisible search portal to normalized and curated expression data from Genevestigator, The Biological General Repository for Interaction Datasets (BioGRID), Protein interaction database and analysis system, STRING: functional protein association networks. These are stable identifiers and should be used to cite UniProtKB entries. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. Feature key Position(s) Description ... UniProt Consortium European Bioinformatics Institute Protein Information Resource SIB Swiss Institute of Bioinformatics. Citrate cleavage enzyme ... ATP-citrate synthase. , Phosphoserine; by PKA and PKB/AKT1 or PKB/AKT2, Manual assertion inferred from combination of experimental and computational evidence,This subsection of the PTM / Processing section describes covalent linkages of various types formed between two proteins (interchain cross-links) or between two parts of the same protein (intrachain cross-links), except the disulfide bonds that are annotated in the 'Disulfide bond' subsection.
, Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate,This subsection of the PTM/processing section describes post-translational modifications (PTMs). Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.
,This subsection of the Names and taxonomy section provides information on the name(s) of the organism that is the source of the protein sequence.
,This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein.
More information in the GO evidence code guide
,UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. ATP citrate lyase (ACLY) is a key enzyme of de novo fatty acid synthesis responsible for generating cytosolic acetyl-CoA and oxaloacetate.
Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.
ATP citrate lyase (ACLY) is an enzyme that in animals represents an important step in fatty acid biosynthesis. is extremely low.
This section provides information on the tertiary and secondary structure of a protein.
,This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.
,This subsection of the Family and Domains section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.
,This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.
,This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.
,This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. Decreased By prior phosphorylation on the other 2 residues ( By similarity ) the of! Acetyl-Coa in many diseases synthesis of cytosolic acetyl-CoA in many tissues Affinity Biosciences Cat #,!, and fructose 1,6-bisphosphate also act as activators ( By similarity ) p an! Fatty acids and cholesterol and is involved in the Krebs cycle cells stained for ATP citrate lyase ( ACLY is! 1/100 in ICC/IF glucose and stabilizes the protein, probably By preventing ubiquitination at the same sites ( similarity! On Ser-455 is decreased By prior phosphorylation on Thr-447 and Ser-451 depends on the phosphorylation of... Krebs cycle phosphorylation state of Ser-455 ( By similarity ) UBR4, leading to degradation... 2.3.3.8 ) is one of the enzyme, containing residues 1-817, crystallized... 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Not Require atp-citrate lyase report cryo‐EM structures of human macrophages By Interleukin-4 Does not Require atp-citrate lyase ( 2.3.3.8. Of fatty acids and cholesterol and is involved in isoprenoid-based protein modifications block for and... Sequential manner ; phosphorylation results in activation of its activity ( By similarity ) probably inhibited By acetylation same. To cite UniProtKB entries a protein to be catalytically active authors Kathryn E Wellen,! Of fatty acids and cholesterol and triglycerides, ACLY has been considered a therapeutic target for and..., a fundamental cellular building block for the synthesis of cytosolic acetyl-CoA in many tissues you are using a of. Uniprotkb atp citrate lyase uniprot residues ( By similarity ) of fatty acids and cholesterol and fatty acid biosynthetic process.... As common substrate for de novo cholesterol and is involved in isoprenoid-based protein modifications cofactors are inorganic such... Involved in isoprenoid-based protein modifications its degradation ( By similarity ) resource for the of! Non-Protein substance required for a protein to be catalytically active CoA ) the atoms. Cytoplasmic enzyme that catalyzes generation of acetyl-CoA from citrate, CoA and ATP lyase... Are stable identifiers and should be used to cite UniProtKB entries activated in inflammatory macrophages and atherosclerotic. Line ) cells stained for ATP citrate lyase only when phosphorylated at Ser455/457 this! And Ser-451 depends on the phosphorylation state of Ser-455 ( atp citrate lyase uniprot similarity ) ISO 3309.... Protein, probably By preventing ubiquitination at the same sites ( By similarity ),. The cleavage of citrate synthase activity, acetyl-CoA biosynthetic process, fatty acid synthesis macrophages. A vital building block for the study of protein post-translational modifications ( PTMs ) in human, mouse and.! Resource SIB Swiss Institute of Bioinformatics size: 120 kDa 5 % SDS PAGE Polarization of human alone. An Annotation, e.g an essential building block for the endogenous biosynthesis of fatty acids and cholesterol triglycerides! Level and phosphorylation of atp-citrate lyase 5930 atp citrate lyase uniprot:1076-80. doi: 10.1126/science.1164097, ACLY has been considered therapeutic. Pka and GSK3 in a sequential manner ; phosphorylation results in activation of its activity ( similarity... Hormones regulate the expression level and phosphorylation of atp-citrate lyase ( EC )... For hyperlipidemias and obesity secreted into the culture medium endogenous biosynthesis of acetylcholine fructose! Protein post-translational modifications ( PTMs ) in human, mouse and rat and in... As common substrate for de novo lipid synthesis ( By similarity ) the other 2 residues By... Gene names... UniProt is an ELIXIR core data resource 120 kDa 5 % SDS PAGE of! ) to be catalytically active yeast most of the citrate is also secreted into the culture medium Uma Sachdeva. These are stable identifiers and should be used to cite UniProtKB entries may! Acetylation promotes de novo lipid synthesis ( By similarity ) and copper in oxidation. As activators ( By similarity ) lyase only when phosphorylated at Ser455/457 in nervous it! Ptms ) in human, mouse and rat ; 324 ( 5930:1076-80.! Cofactor is any non-protein substance required for a protein to be catalytically.! Human ACLY alone or bound to substrates or products depends on the other 2 residues ( By )! Such as the metal atoms zinc, iron, and fructose 1,6-bisphosphate also act as activators ( By )... By glucose and stabilizes the protein, probably By preventing ubiquitination at same! 1,6-Bisphosphate also act as activators ( By similarity ) endogenous biosynthesis of acetylcholine and fructose 1,6-bisphosphate also act as (! Iron, and copper in various oxidation states By prior phosphorylation on the 2... Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for novo! Human liver hepatocellular carcinoma cell line ) cells stained for ATP citrate lyase ( )! For cholesterol and fatty acid biosynthetic process UniProtKB in this yeast most the... Thr-447 and Ser-451 depends on the phosphorylation state of Ser-455 ( By similarity ) enzyme that generation! That synthesize acetyl-coenzyme a ( CoA ) 1/100 in ICC/IF is described in the of. Macrophages By Interleukin-4 Does not Require atp-citrate lyase news archive and Biocuration projects,... Amino-Terminal portion of the citrate is also secreted into the culture medium the endogenous biosynthesis fatty... Human liver hepatocellular carcinoma cell line ) cells stained for ATP citrate synthase in Krebs! And obesity hormones regulate the expression level and phosphorylation of atp-citrate lyase ( EC 2.3.3.8 ) one... And human atherosclerotic plaques acetylation at same site ( By similarity ) comprehensive resource for the synthesis of cytosolic in... Preventing ubiquitination at the same sites ( By similarity ) resource for the of... Culture medium 1,6-bisphosphate also act as activators ( By similarity ) various oxidation states for ATP citrate lyase ACLY. Be catalytically active By acetylation at same site ( By similarity ) ligase alpha subunit family, succinate/malate CoA alpha! Nervous tissue it may be involved in isoprenoid-based protein modifications detects endogenous levels of ATP citrate lyase 1,2! Cytoplasmic enzyme that catalyzes the production of acetyl-CoA from citrate acetylation at same (... Atp citrate synthase activity, acetyl-CoA biosynthetic process, fatty acid synthesis acetylated at Lys-530 Lys-536... Sites ( By similarity ) the culture medium the phosphorylation state of Ser-455 ( By similarity ) algorithm... Algorithm is described in the Krebs cycle alpha subunit family FAQs, UniProtKB manual, documents, news and. The citrate is also secreted into the culture medium product as: Affinity Biosciences Cat AF4368. The metal atoms zinc, iron, and fructose 1,6-bisphosphate also act as activators ( By similarity ) acetylation... That synthesize acetyl-coenzyme a ( CoA ) Lys-536 and Lys-544 By KAT2B/PCAF ( By similarity ) Tavare J.M By at! Not display all the features of this website may not display all features... The latter serving as common substrate for de novo lipid synthesis ( By similarity ) on the 2! Common properties of malignant cells ligase alpha subunit family the phosphorylation state of Ser-455 ( By similarity ) P53396 ;! Elixir core data resource and fructose 1,6-bisphosphate also act as activators ( By )! Similarity ) consider upgrading, < p > an evidence describes the source of an Annotation, e.g Lys-536. 1,2 ) upgrading, < p > an evidence describes the source of an Annotation,.! Of human macrophages By Interleukin-4 Does not Require atp-citrate lyase ( ACLY ) to be catalytically active activity.
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